The Working Group is composed of electrophysiology representatives from the INCF network, Human Brain Project (HBP), Neurodata Without Borders (NWB) Core Development Team, and Stimulating Peripheral Activity to Relieve Conditions (SPARC), sharing use cases from the respective projects.The initial use cases are from intracellular electrophysiology, with good coverage over most typical ICEPhys protocols. This schema is also useful for other 1D signals over time that are used as stimuli. In addition, the ontology defines a specification for parameterizing the stimulus templates. This is a strategy for stimulus description that should eventually be easily extendable to 2D (i.e. visual) stimuli, which is another large class of stimuli that is common in NWB.
This Working Group coordinates common efforts for defining and describing cell types across neuroscience, to reduce duplicate efforts and to improve interoperability and reuse of cell type-specific data collected across groups. The key focus is facilitating interactions between groups collecting large-scale datasets used to define novel cell types (such as single-cell transcriptomics) and ontologists and tool developers who have considerable experience curating cell type-specific data, with the goal to reduce duplicate efforts and to improve interoperability and reuse of cell type-specific data collected across groups.
The coordination of this effort has now moved to the Allen Institute, as part of their work on cell nomenclatures which began with the Cell Type Ontology Workshop held at the Allen Institute in Seattle in 2019. The outcome of the workshop was a framework for developing nomenclature: the Common Cell Type Nomenclature, or CCN. It was initially applied to brain cells and types, and intended to encompass existing naming strategies used in publications across diverse research teams, to allow tracking of many different taxonomies across diverse areas of bioscience. The CCN is described in this 2020 paper in eLife. To learn more about the current activities of the CCN, visit: https://portal.brain-map.org/explore/classes/nomenclature.