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G A Johnson

Full name

G A Johnson

Affiliation

Duke University

Address

Rm 141 D Bryan Neuroscience Bldg
Research Dirve
27710
Durham
United States

Email

gjohnson(at)duke.edu

Home page

http://www.civm.duhs.duke.edu

Phone

Office: 919 684 7754

Research Areas

  • Digital atlasing
  • Neuroimaging

Keywords

Magnetic Resonance Imaging, Microscopy, Digital Atlasing, Diffusion Tensor,Aging, Toxicology

Research focus

Dr. Johnson is director of the Duke CIVM. He is currently developing a digital atlas for mouse brain research based on very hi (21 micron) 3D MR data with correlated optical histology.

Research description

Dr. Johnson is the Charles E. Putman Professor of Radiology, Physics, and Biomedical Engineering at Duke University. He was responsible for installing the world’s first clinical high field (1.5T) MRI system at Duke in 1983. He established the Duke Center for In Vivo Microscopy in 1985 (NIH/NCRR P41 RR05959). He modified the prototype 1.5 T system to produce the first MR microscopy images of the rat brain in 1986 (J. Mag. Res. 68:129-137, 1986). He developed the technology and coined the term for magnetic resonance histology (MRH) in 1993 (Mag Res Quart 9(1):1-30,1993. More recently he has focused on extending the spatial resolution of MRH and making high throughput imaging accessible to neuroscientists via the Mouse Brain Bioinformatics Research Network (Neuroimage 37(1):82-89, 2007). More specifically he and his team have generated the highest resolution MR images yet acquired of the mouse brain (21.5 um isotropic spatial resolution). A wide range of image contrast has been explored highlighting the cytoarchitecture of the mouse brain in 3 dimensions. This data has been paired with matched Nissl sections of the same brains, segmented, registered to a standardized coordinate system and placed in a flexible viewing tool- all of which are freely available to the neuroscience community via the CIVM web portal. This multidimensional atlas provides the image-based entry to Waxholm Space- a unified space for coordinating neuroscience research. The work has been sponsored by the Mouse Bioinformatics Research Network ((U24 RR021760) and the INCF.

INCF activities

Digital Brain Atlasing | Oversight Committee,
Digital Brain Atlasing | Waxholm Space Task Force
Profile updated: 2011-11-17
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